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Prednisone & Weight Gain (The Studies) Many studies have been conducted to evaluate the side effect profile of prednisone and similar corticosteroid medicationson weight gain. Several studies have been conducted with prednisone or other corticosteroid medications for chronic obstructive pulmonary disease (COPD), chronic respiratory, asthma and other health conditions. Studies on weight gain in patients with COPD have ranged from 16-45lbs (7"-20"). Some of the studies report a reduction in both total weight and body fat mass but these reductions are not consistent to what the manufacturer claims and have to be verified independently by another organization. There are few studies looking at weight gain with prednisone, and some have shown some weight gain, but they are either too small or not statistically significant. There are also no studies that specifically evaluate weight gain in people with asthma. Oral Prednisone & Heart Disease (Studies and Discussion) There have been several studies that have been conducted that examine oral prednisone and heart disease. The main conclusion reached from the studies is that people taking oral prednisone in high doses for very long periods, especially those over the age of 40 years, have an increased prevalence of heart disease. This has been found to include congestive heart failure (CHF) and arrhythmias. The majority of these studies have been for short term prednisone dosages of 10mg once daily (i.e. 3mg every 4 hours). A summary of the studies and the results can be found below: Study: Effect of Oral Prednisone, 10-20mg/min, on Heart and Circulatory Conditions (M. E. S. D. L, et al., JAMA 1991;265:1312-1320) Study: Effect of Oral Prednisone, 10-20mg/min, on Heart and Circulatory Conditions (M. E S D. L, et al., JAMA 1991;265:1312-1320) Study: Effect of Oral Prednisone, 20-40mg/d (G. L. N. B. and R. B. E. A.) Study: Effect of Oral Prednisone, 20-40mg/d (G. L. N. B. and R. B. E. A.) Study: Effect of Oral Prednisone, 40-80mg/day (M. M. V. V. and A. F. M. L) Study:Effect of Oral Prednisone, 40-80mg/day (M. M. V. V. and A. F. M. Similar articles: